24730-10-7
中文名稱
甲磺酸雙氫麥角汀
英文名稱
DIHYDROERGOCRISTINE MESYLATE
CAS
24730-10-7
分子式
C36H45N5O8S
分子量
707.84
MOL 文件
24730-10-7.mol
更新日期
2023/03/20 15:41:21
24730-10-7 結(jié)構(gòu)式
基本信息
中文別名
甲磺酸雙氫麥角汀甲磺酰雙氫麥角克堿
二氫麥角新堿甲磺酸鹽
雙氫麥角汀 甲磺酸鹽
二氫麥角亭甲烷硫酸鹽
二氫麥角堿(甲磺酸鹽)
甲磺酸雙氫麥角汀 EP標(biāo)準(zhǔn)品
英文別名
C13168DHEC (mesylate)
dihydroergocristinmesilat
DIHYDROERGOCRISTINE MESYLATE
Dihydroergocristine mesilate CRS
DIHYDROERGOCRISTINE METHANESULFONATE
Dihydroergocristine mesilate (D1945000)
dihydroergocristine methanesulfonate salt
DIHYDROERGOCRYSTINE METHANESULFONATE SALT
Dihydroergotamine Mesilate Impurity E as Mesilate
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)210 °C
儲(chǔ)存條件Store at RT
溶解度H2O: 10 mg/mL
溶解度在水中的溶解度10 mg/mL
形態(tài)neat
顏色White to off-white
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H303
危險(xiǎn)品運(yùn)輸編號(hào)UN 1544 6.1/PG 2
危險(xiǎn)品運(yùn)輸編號(hào)UN 1544 6.1/PG 2
WGK Germany2
WGK Germany2
RTECS號(hào)KE7600000
危險(xiǎn)等級(jí)6.1(b)
包裝類別III
海關(guān)編碼29396900
甲磺酸雙氫麥角汀價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-N2319 | 甲磺酸雙氫麥角汀 Dihydroergocristine mesylate | 24730-10-7 | 5mg | 1500元 |
| 2024/11/08 | HY-N2319 | 甲磺酸雙氫麥角汀 Dihydroergocristine mesylate | 24730-10-7 | 10mM * 1mLin DMSO | 2336元 |
| 2024/11/08 | HY-N2319 | 甲磺酸雙氫麥角汀 Dihydroergocristine mesylate | 24730-10-7 | 10mg | 2400元 |
常見問題列表
生物活性
Dihydroergocristine mesylate (DHEC mesylate) 是γ-secretase (GSI) 的抑制劑, 可減少阿爾茨海默氏病淀粉樣蛋白 β 肽 (amyloid-β) 的產(chǎn)生, 與 γ-secretase 和 Nicastrin 結(jié)合的平衡解離常數(shù) (Kd) 值分別為 25.7 nM 和 9.8 μM。體外研究
Dihydroergocristine (DHEC) (2-20 μM; 24 hours) has an IC 50 value of 25?μM for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability. Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells.
Western Blot Analysis
| Cell Line: | WT HEK293 cells; Fibroblast cells |
| Concentration: | 2 μM, 5 μM, 10 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Increased APP-CTFs accumulation in a dose-dependent manner. |