2448286-21-1
中文名稱(chēng)
GNE 220 Hydrochloride
英文名稱(chēng)
GNE 220 Hydrochloride
CAS
2448286-21-1
分子式
C??H??ClN?
分子量
475
MOL 文件
2448286-21-1.mol
2448286-21-1 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
GNE 220 (hydrochloride) 是一種有效的選擇性 MAP4K4 抑制劑，其 IC50 值為 7 nM。靶點(diǎn)
|
MAP4K4 7 nM (IC 50 ) |
MAP4K5 9 nM (IC 50 ) |
MAP4K6 1.1 μM (IC 50 ) |
DMPK 476 nM (IC 50 ) |
體外研究
GNE-220 also inhibits a few other kinases with IC 50 s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM + retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1 + long focal adhesions (FAs).