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2439-02-3

中文名稱 Kynurenic acid sodium salt
英文名稱 Kynurenic acid sodium salt
CAS 2439-02-3
分子式 C10H6NNaO3
分子量 230.196
MOL 文件 2439-02-3.mol
2439-02-3 結構式 2439-02-3 結構式

基本信息

中文別名
化合物 T22892
4-羥基喹啉-2-甲酸鈉
英文別名
Kynurenic acid (sodium)
Kynurenic acid sodium salt
4-Hydroxyquinoline-2-carboxylicacidsodiumsalt

物理化學性質

儲存條件Store at RT
溶解度DMSO : 50 mg/mL (235.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
形態(tài)粉末
顏色Pale
Kynurenic acid sodium salt價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/11/08HY-107512Kynurenic acid sodium salt
Kynurenic acid sodium
2439-02-3100mg500元
2024/11/08HY-107512Kynurenic acid sodium salt
Kynurenic acid sodium
2439-02-310mM * 1mLin DMSO550元

常見問題列表

生物活性
Kynurenic acid sodium 是一種內源性色氨酸代謝物,是針對靶點 NMDA, glutamate, α7 nicotinic acetylcholine receptor 的光譜性拮抗劑。Kynurenic acid sodium 也是 GPR35/CXCR8 的激動劑。
靶點

Target: GPR35, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine

體外研究

GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G qi/o chimeric G proteins. Kynurenic acid stimulates [ 35 S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC 50 in the low micromolar range.

體內研究

Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals.

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