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2417718-25-1

中文名稱(chēng) 化合物VT104
英文名稱(chēng) 2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
CAS 2417718-25-1
分子式 C25H19F3N2O
分子量 420.43
MOL 文件 2417718-25-1.mol
更新日期 2025/01/07 08:45:01
2417718-25-1 結(jié)構(gòu)式 2417718-25-1 結(jié)構(gòu)式

基本信息

中文別名
化合物VT104
英文別名
VT-104
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-

物理化學(xué)性質(zhì)

沸點(diǎn)583.3±50.0 °C(Predicted)
密度1.259±0.06 g/cm3(Predicted)
溶解度DMSO: 2mg/mL, clear
酸度系數(shù)(pKa)13.30±0.46(Predicted)
形態(tài)Solid
顏色White to off-white

應(yīng)用領(lǐng)域

用途一
VT-104 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT104 is an analog of VT102, which has improved potency and good oral pharmacokinetics in mice. VT104 prevented palmitoylation of the TEAD1 protein. VT104 showed excellent orally bioavailability and long half-lives, which inhibits tumor growth and also lead to shrinkage of established tumors in preclinical models of human mesothelioma CDX models deficient in functional Merlin.

圖譜信息

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