24168-96-5
中文名稱
硝酸異康唑
英文名稱
Isoconazole nitrate
CAS
24168-96-5
EINECS 編號(hào)
246-051-4
分子式
C18H15Cl4N3O4
MDL 編號(hào)
MFCD01721647
分子量
479.14
MOL 文件
24168-96-5.mol
更新日期
2024/11/04 11:42:49
24168-96-5 結(jié)構(gòu)式
基本信息
中文別名
1-[2-(2,4-二氯苯基)-2-[(2,6-二氯苯基)甲氧基]乙基]-1H-咪唑單硝酸鹽硝酸異康唑
氯氨酮雜質(zhì)A
硝酸鄰氯益康唑
英文別名
1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrateISOCONAZOLE NITRATE
1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazolium nitrate
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI)
Adestan G 100
Fazol
Gyno-Travogen
Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]-, mononitrate (8CI)
R 15454
Travogen
Travogyn
1-(2-(2,4-Dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-1H-imidazole nitrate
Gyno-travozen
所屬類別
原料藥：其它抗生素類藥物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶或結(jié)晶性粉末，無(wú)味，不溶于水，乙醚，稍溶于氯仿，乙醇，熔點(diǎn)178-182°C，比旋度-0.1°- +0.1°
熔點(diǎn)178-182°C
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).
形態(tài)neat
顏色白色至灰白色
Merck14,5160
CAS 數(shù)據(jù)庫(kù)24168-96-5(CAS DataBase Reference)
常見問題列表
概述
硝酸異康唑是一種具有廣譜抗真菌作用的咪唑類抗真菌藥，對(duì)白色念珠菌、表皮癬菌及某些革蘭陽(yáng)性菌均有抑制作用。硝酸異康唑于1979年在法國(guó)上市，因其具有療效顯著，毒副作用低等優(yōu)點(diǎn)，具有廣闊的市場(chǎng)前景。生物活性
Isoconazole nitrate 是一種唑類抗真菌藥物。體外研究
Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure.
Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells.