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24003-58-5

中文名稱 N-ETHYLLIDOCAINE BROMIDE
英文名稱 N-ETHYLLIDOCAINE BROMIDE
CAS 24003-58-5
分子式 C16H27N2OBr
分子量 343.31
MOL 文件 24003-58-5.mol
更新日期 2025/01/07 08:30:55
24003-58-5 結(jié)構(gòu)式 24003-58-5 結(jié)構(gòu)式

基本信息

中文別名
化合物 T16707
英文別名
N-ETHYLLIDOCAINE BROMIDE
[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide
2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE

物理化學(xué)性質(zhì)

儲(chǔ)存條件Desiccate at RT
溶解度insoluble in EtOH; ≥10.5 mg/mL in H2O; ≥25.55 mg/mL in DMSO
形態(tài)結(jié)晶固體
顏色白色
水溶解性溶于水至100mM

常見(jiàn)問(wèn)題列表

生物活性
QX-314 bromide 是一種膜不滲透的鈉離子通道永久性電荷阻滯劑。
靶點(diǎn)

sodium channel

體外研究

QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro .
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death .
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca 2+ currents are on average < 10% of control amplitude .
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- .

體內(nèi)研究

QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.

Animal Model: Male Sprague-Dawley rats (250-290 g)
Dosage: 1.6 mg/kg
Administration: Intracutaneous injection
Result: Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
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