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23815-89-6

中文名稱 ARG-PRO-PRO-GLY-PHE
英文名稱 H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
CAS 23815-89-6
分子式 C27H40N8O6
分子量 572.66
MOL 文件 23815-89-6.mol
更新日期 2024/12/16 10:25:32
23815-89-6 結(jié)構(gòu)式 23815-89-6 結(jié)構(gòu)式

基本信息

中文別名
1-5-血管舒緩激肽
2-[[2-[[1-[1-[2-AMINO-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]PYRROLIDINE-2-CARBONYL]PYRROLIDINE-2-CARBONYL]AMINO]ACETYL]AMINO]-3-PHENYLPROPANOIC ACID
英文別名
RPPGF
1-5-Bradykinin
BRADYKININ (1-5)
ARG-PRO-PRO-GLY-PHE
1-5-Bradykinin (9CI)
Arg-Pro-Pro-Gly-Phe-OH
BRADYKININ FRAGMENT 1-5
39: PN: WO0112656 SEQID
H-Arg-Pro-Pro-Gly-Phe-OH
ARG-PRO-PRO-GLY-PHE ACETATE

物理化學(xué)性質(zhì)

密度1.46±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度Soluble in DMSO
酸度系數(shù)(pKa)3.50±0.10(Predicted)
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

WGK Germany3
ARG-PRO-PRO-GLY-PHE價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-P1488ARG-PRO-PRO-GLY-PHE
Bradykinin (1-5)
23815-89-61mg550元
2024/11/08HY-P1488ARG-PRO-PRO-GLY-PHE
Bradykinin (1-5)
23815-89-65mg1800元

常見問題列表

生物活性
Bradykinin (1-5) 是 Bradykinin 的主要穩(wěn)定代謝物,由血管緊張素轉(zhuǎn)換酶 (ACE) 經(jīng)蛋白水解作用形成。
體內(nèi)研究

Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED 50 of 183±2 pmol/min.

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