2341841-07-2
2341841-07-2 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
JMS-17-2 hydrochloride 是一種有效的選擇性 CX3CR1 拮抗劑，IC50 為 0.32 nM。JMS-17-2 hydrochloride 降低乳腺癌細(xì)胞的轉(zhuǎn)移和定植。靶點(diǎn)
IC50: 0.32 nM (CX3CR1)
體內(nèi)研究
JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice.
| Animal Model: | SCID mice (~25g) with MDA-231 xenograft |
| Dosage: | 10 mg/kg |
| Administration: | Aministered i.p.; twice a day for three weeks |
| Result: | Caused a dramatic reduction of tumors in both skeleton and visceral organs. |