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231957-54-3

中文名稱 MIV-150
英文名稱 MIV-150
CAS 231957-54-3
分子式 C19H17FN4O3
分子量 368.36
MOL 文件 231957-54-3.mol
231957-54-3 結(jié)構(gòu)式 231957-54-3 結(jié)構(gòu)式

基本信息

中文別名
化合物 T16081
英文別名
PC 815
MIV-150
MIV150,MIV 150
1-(5-cyanopyridin-2-yl)-3-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-

物理化學性質(zhì)

儲存條件-20°C儲存
溶解度DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL; Ethanol: 0.25 mg/mL
形態(tài)結(jié)晶固體

常見問題列表

生物活性
MIV-150 是 NNTR 的一個抑制劑,可以抑制 HIV-1 和 HIV-2 感染,其對 HIV-1/HIV-2 的 EC50 值為 <1 nM。
靶點

HIV-1

<1 nM (EC 50 )

HIV-2

<1 nM (EC 50 )

體外研究

The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC 50 of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC 50 of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150.

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