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2252488-69-8

中文名稱 LJ570
英文名稱 LJ570
CAS 2252488-69-8
分子式 C27H22O3
分子量 394.47
MOL 文件 2252488-69-8.mol
2252488-69-8 結(jié)構(gòu)式 2252488-69-8 結(jié)構(gòu)式

基本信息

中文別名
化合物L(fēng)J570
英文別名
LJ570
1,1'-Biphenyl]-4-propanoic acid,α-([1,1'-biphenyl]-4-yloxy)-,(αS)-
[1,1'-Biphenyl]-4-propanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)-

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度溶于二甲基亞砜

應(yīng)用領(lǐng)域

用途一
LJ570 is the first PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. LJ570 is a potent partial agonist of both PPARα and γ subtypes. LJ570 inhibited the Cdk5-mediated phosphorylation of PPARγ at serine 273 that is currently considered the mechanism by which some PPARγ partial agonists exert antidiabetic effects similar to thiazolidinediones, without showing their typical side effects. LJ570 may be useful for treatment of dyslipidemic type 2 diabetes.

圖譜信息

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