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2241027-61-0

英文名稱 MEDS433
CAS 2241027-61-0
分子式 C20H11F4N3O2
分子量 401.32
MOL 文件 2241027-61-0.mol
2241027-61-0 結(jié)構(gòu)式 2241027-61-0 結(jié)構(gòu)式

基本信息

英文別名
MEDS433

應(yīng)用領(lǐng)域

用途一
MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells.
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