2238822-07-4
英文名稱
5H-Pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-6,7-dihydro-6-(methylamino)-, (6S)-
CAS
2238822-07-4
分子式
C20H25N5O4S
分子量
431.51
MOL 文件
2238822-07-4.mol
2238822-07-4 結(jié)構(gòu)式
基本信息
英文別名
5H-Pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-6,7-dihydro-6-(methylamino)-, (6S)-物理化學(xué)性質(zhì)
密度1.63±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)4.47±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
GDC-2394 is a A Potent and Selective NLRP3 Inhibitor with an in vitro and in vivo safety profile suitable for advancement into human clinical trials. GDC 2394 Inhibits In Vivo Production of IL-1β in an Acute Mouse Peritonitis Model. GDC 2394 Reduces Paw Swelling and Pain in a Functional Rat Model of Gouty Arthritis.