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2231079-74-4

中文名稱 NCT-505
英文名稱 NCT-505
CAS 2231079-74-4
分子式 C27H28FN5O3S
分子量 521.61
MOL 文件 2231079-74-4.mol
2231079-74-4 結構式 2231079-74-4 結構式

基本信息

中文別名
化合物NCT-505
英文別名
NCT-505 free base
1-(6-Fluoro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)-4-phenylpiperidine-4-carbonitrile
4-Piperidinecarbonitrile, 1-[6-fluoro-3-[[4-(methylsulfonyl)-1-piperazinyl]carbonyl]-4-quinolinyl]-4-phenyl-

物理化學性質

儲存條件-20°C儲存
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white

應用領域

用途一
NCT-505 is an Orally Bioavailable aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitor with Potent Cellular Activity (IC50 = 7 nM). NCT-505 demonstrated target engagement in a cellular thermal shift assay (CETSA), inhibited the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiated the cytotoxicity of paclitaxel in SKOV-3-TR, a paclitaxel resistant ovarian cancer cell line. NCT-505 also exhibit high specificity over other ALDH isozymes and unrelated dehydrogenases.
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