2229037-09-4
2229037-09-4 結(jié)構(gòu)式
基本信息
英文別名
TL 13-110Acetamide, N-[2-[2-[2-[4-[4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2,3-dihydro-1,3-dioxo-2-(2-oxo-3-piperidinyl)-1H-isoindol-4-yl]amino]-
常見(jiàn)問(wèn)題列表
生物活性
TL13-110 是 一種 TL13-112 (HY-123919) 的陰性對(duì)照，是一種有效的 ALK 抑制劑，IC50 為 0.34 nM。TL13-110 不會(huì)降解細(xì)胞中的 ALK。靶點(diǎn)
IC50: 0.34 nM (ALK); 81 μM (Cereblon)
體外研究
TL13-110 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC 50 values of 9080 nM, 23.1 nM, 21.2 nM, and 480 nM, respectively.