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2227366-51-8

中文名稱 達(dá)巴萬星鹽酸鹽
英文名稱 Dalbavancin hydrochloride
CAS 2227366-51-8
更新日期 2025/02/27 16:33:51
分子式 C88H101Cl3N10O28
分子量 1853.17
MOL 文件 2227366-51-8.mol
2227366-51-8 結(jié)構(gòu)式 2227366-51-8 結(jié)構(gòu)式

基本信息

中文別名
鹽酸道古霉素
達(dá)巴萬星鹽酸鹽
所屬類別
原料藥：抗生素類藥物

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度DMSO: ≥ 24 mg/mL (12.95 mM)
形態(tài)Solid
顏色White to light yellow
水溶解性Water: 50 mg/mL (26.98 mM)

常見問題列表

生物活性
Dalbavancin hydrochloride(MDL-63397 hydrochloride) 是一種半合成的脂糖肽抗生素，對(duì)革蘭氏陽性細(xì)菌具有有效的殺菌活性。Dalbavancin hydrochloride 抑制金黃色葡萄球菌和炭疽芽孢桿菌的 MIC90 分別為 0.06 μg/mL 和 0.25 μg/mL。
體外研究

Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.

體內(nèi)研究

Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.

Animal Model: Female BALB/c mice (6-8 weeks) challenged with Ames strain of B. anthracis
Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection; every 36 h or 72 h; for 14 days
Result: The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
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