2227019-45-4
中文名稱(chēng)
AURORA INHIBITOR 1
CAS
2227019-45-4
2227019-45-4 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
Aurora inhibitor 1 是一種有效的 Aurora 抑制劑，抑制 Aurora A 和 Aurora B 激酶的 IC50 分別 ≤4 nM 和 ≤13 nM。靶點(diǎn)
|
Aurora A 4 nM (IC 50 ) |
Aurora B 13 nM (IC 50 ) |
體外研究
Aurora inhibitor 1 (Compound 16) exhibits K d values of 0.01?nM for both Aurora A and Aurora B kinase.
體內(nèi)研究
Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally.