2221948-96-3
2221948-96-3 結(jié)構(gòu)式
基本信息
英文別名
Di-NHS Ester-PEG25Bis-dPEG25-NHS ester
4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-Pentacosaoxanonaheptacontanedioic acid, 1,79-bis(2,5-dioxo-1-pyrrolidinyl) ester
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
沸點1081.3±75.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Bis-PEG25-NHS ester 是一種 PROTAC 連接橋，屬于 PEG 類和 Alkyl/ether 類。Bis-PEG25-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG25-NHS ester 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成。靶點
|
PEGs
|
Alkyl/ether
|
Cleavable
|
體外研究
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.