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2179-37-5

中文名稱 平痙可寧
英文名稱 bencyclane
CAS 2179-37-5
分子式 C19H31NO
分子量 289.46
MOL 文件 2179-37-5.mol
2179-37-5 結(jié)構(gòu)式 2179-37-5 結(jié)構(gòu)式

基本信息

中文別名
哈里多
芐環(huán)烷
平痙可寧
芐環(huán)庚烷
胺芐環(huán)已醚
英文別名
Benzcyclan
bencyclane
Benzcyclane
3-[1-(benzyl)cycloheptoxy]propyl-dimethyl-amine
N,N-dimethyl-3-[1-(phenylmethyl)cycloheptyl]oxypropan-1-amine
N,N-dimethyl-3-[1-(phenylmethyl)cycloheptyl]oxy-propan-1-amine
1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)cycloheptyl]oxy]-

物理化學性質(zhì)

沸點bp3 146-156°
密度0.97±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)pKa 8.94±0.04(40%EtOH t=25.0) (Uncertain)
形態(tài)Oil
顏色Colorless to light yellow

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302

常見問題列表

生物活性
Benzcyclane (Bencyclane) 是血小板聚集抑制劑和有效研究各種外周循環(huán)障礙的血管擴張劑。
體內(nèi)研究

Benzcyclane, although capable of aggregating platelets by itself at very high concentrations, shows a striking inhibitory effect, over a wide range of concentrations, both on platelet aggregation induced by ADP, epinephrine or collagen and on platelet adhesiveness to glass or collagen. Clot retraction is also clearly inhibited. Benzcyclane induces use-dependent inhibition of Na channels in muscle, similarly as do class 1 antiarrhytnmic drugs. Inhibition was observed with both normal and cevadine-modified Na channels.

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