214558-72-2
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2025/02/08 | HY-101679 | YM-58790 | 214558-72-2 | 1 mg | 1772元 |
2025/02/08 | HY-101679 | YM-58790 | 214558-72-2 | 5 mg | 3900元 |
2025/02/08 | HY-101679 | 214558-72-2 YM-58790 | 214558-72-2 | 10 mM * 1 mLin DMSO | 3998元 |
常見問題列表
Ki: 15 nM (M3 muscarinic receptor)
YM-58790 shows potent inhibitory effect on urinary bladder contraction, but has little effect on bradycardia. YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion in vitro.
YM-58790 (3 mg/kg, i.v.) does not inhibit oxotremorine-induced tremor in mice. The effect of YM-58790 on McN-A343-induced pressor in pithed rats, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.