2134169-43-8
中文名稱
2134169-43-8
英文名稱
Formamide, N-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indol-1-yl]methyl]bicyclo[1.1.1]pent-1-yl]-
CAS
2134169-43-8
分子式
C32 H35 F3 N8 O S
分子量
636.73
MOL 文件
2134169-43-8.mol
2134169-43-8 結(jié)構(gòu)式
基本信息
英文別名
MI-3454Formamide, N-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indol-1-yl]methyl]bicyclo[1.1.1]pent-1-yl]-
應(yīng)用領(lǐng)域
用途一
MI-3454 is a highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis.