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2128304-54-9

中文名稱 化合物 TQ0242L
英文名稱 Fenebrutinib (GDC-0853) HCl
CAS 2128304-54-9
分子式 C37H45ClN8O4
分子量 701.27
MOL 文件 2128304-54-9.mol
2128304-54-9 結(jié)構(gòu)式 2128304-54-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 TQ0242L
英文別名
RG7845
RG-7845
RG 7845
Fenebrutinib HCl
Fenebrutinib (GDC-0853) HCl

應(yīng)用領(lǐng)域

用途一
Fenebrutinib, also known as GDC-0853, is orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.
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