211555-08-7
中文名稱
3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚
英文名稱
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
CAS
211555-08-7
分子式
C16H15N3O3
分子量
297.31
MOL 文件
211555-08-7.mol
更新日期
2024/12/15 19:35:21
211555-08-7 結(jié)構(gòu)式
基本信息
中文別名
3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚3-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚
3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚, >98%
英文別名
Janex 3WHI-P180, >98%
WHI-P180(Janex 3)
WHI P180
JANEX3
WHIP180
JANEX-3
3-(6,7-dimethoxyquinazolin-4-ylamino)phenol
3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference)
物理化學(xué)性質(zhì)
沸點(diǎn)476.5±40.0 °C(Predicted)
密度1.336±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)9.58±0.10(Predicted)
形態(tài)粉末
顏色White to off-white
3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | S6520 | 3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚 WHI-P180 | 211555-08-7 | 5mg | 794.68元 |
常見(jiàn)問(wèn)題列表
生物活性
WHI-P180是多種激酶的抑制劑，對(duì)RET (c-RET)和KDR的IC50值分別為4.5 nM和66 nM。靶點(diǎn)
| Target | Value |
|
RET
(Cell-free assay) | 4.5 nM |
|
KDR
(Cell-free assay) | 66 nM |
體內(nèi)研究
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.