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2113650-04-5

中文名稱 BMS-1001
英文名稱 BMS-1001
CAS 2113650-04-5
分子式 C35H35ClN2O7
分子量 631.12
MOL 文件 2113650-04-5.mol
2113650-04-5 結(jié)構(gòu)式 2113650-04-5 結(jié)構(gòu)式

基本信息

中文別名
化合物BMS-1001 HYDROCHLORIDE
英文別名
Inhibitor,BMS 1001,inhibit,ICB,toxicity,BMS1001,immune,checkpoint,BMS 1001 hydrochloride,BMS-1001,BMS1001 hydrochloride,low
(2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride
BMS-1001 hydrochloride (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5- methylbenzyl)-D-serine hydrochloride

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于DMSO
形態(tài)結(jié)晶固體
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338

常見問(wèn)題列表

生物活性
BMS-1001 hydrochloride 是具有口服活性的、人 PD-L1/PD-1 免疫檢查點(diǎn)的抑制劑。BMS-1001 hydrochloride 具有細(xì)胞毒性低的特點(diǎn)。
靶點(diǎn)

PD-L1/PD-1.

體外研究

BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.

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