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2098488-36-7

中文名稱 2098488-36-7
英文名稱 N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
CAS 2098488-36-7
分子式 C19H20N6O6
分子量 428.399
MOL 文件 2098488-36-7.mol
2098488-36-7 結(jié)構(gòu)式 2098488-36-7 結(jié)構(gòu)式

基本信息

中文別名
E3 LINKER
沙利度胺 4'-氧乙酰胺-烷基C4-疊氮化物
英文別名
Azido-Thalidomide
Cereblon Ligand-Linker Conjugates 4
E3 ligase Ligand-Linker Conjugates 18
N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

物理化學(xué)性質(zhì)

溶解度DMF: 12 mg/ml; DMSO: 12 mg/ml; DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white

應(yīng)用領(lǐng)域

用途一
UUN 88367, also known as Azido-Thalidomide is a clickable Thalidomide derivative, used as a building block for cereblon. Azido-Thalidomide targets PROTACs by hijacking cereblon as the E3 ubiquitin ligase component. This product has no formal name at the moment.
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