2097887-21-1
英文名稱
MM-589 TFA salt
CAS
2097887-21-1
物理化學性質(zhì)
儲存條件-20°C, away from moisture
溶解度DMSO : 25 mg/mL (36.40 mM; ultrasonic and warming and heat to 60°C)
肽價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-100869A | 肽 MM-589 TFA | 2097887-21-1 | 1mg | 9980元 |
| 2023/03/20 | HY-100869A | 肽 MM-589 TFA | 2097887-21-1 | 2 mg | 18000元 |
常見問題列表
生物活性
MM-589 TFA 是 WD 重復結(jié)構(gòu)域 5 (WDR5) 和混合譜系白血病 (MLL) 蛋白-蛋白相互作用的有效抑制劑。MM-MM-589 TFA 結(jié)合 WDR5 的 IC50 為 0.90 nM。抑制 MLL H3K4 甲基轉(zhuǎn)移酶活性的 IC50 為 12.7 nM。靶點
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)
Ki: <1 nM (WDR5)
體外研究
MM-589 (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.
Cell Viability Assay
| Cell Line: | MV4-11 and MOLM-13 cells |
| Concentration: | 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 4 days or 7 days |
| Result: | Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM. |