2089035-40-3
中文名稱
化合物 T28463
英文名稱
2-Anthracenesulfonic acid, 1-amino-4-[[4-[(2,4-dimethylphenyl)thio]phenyl]amino]-9,10-dihydro-9,10-dioxo-, sodium salt (1:1)
CAS
2089035-40-3
分子式
C28H23N2NaO5S2
分子量
554.61
MOL 文件
2089035-40-3.mol
2089035-40-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28463 英文別名
PSB16133PSB 16133
PSB-16133
PSB-16133 sodium
2-Anthracenesulfonic acid, 1-amino-4-[[4-[(2,4-dimethylphenyl)thio]phenyl]amino]-9,10-dihydro-9,10-dioxo-, sodium salt (1:1)
應(yīng)用領(lǐng)域
用途一
PSB-16133 is a Potent and Selective Antagonist for the UTP-Activated P2Y4 Receptor. PSB-16133 exhibited an IC50 value of 233 nM, selectivity versus other P2Y receptor subtypes, and is thought to act as an allosteric antagonist. A receptor homology model was built and docking studies were performed to analyze ligand-receptor interactions. Compound 64 represents the most potent and selective P2Y4 receptor antagonist known to date and is therefore anticipated to become a useful tool for studying this scarcely investigated receptor.