207987-59-5
207987-59-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12771 英文別名
RS-601Benzenebutanoic acid, 4-[5,5,6,6,6-pentafluoro-1-[[(4-fluorophenyl)sulfonyl]amino]hexyl]-
物理化學(xué)性質(zhì)
沸點563.3±60.0 °C(Predicted)
密度1.360±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.75±0.10(Predicted)
常見問題列表
生物活性
RS-601 是有效的 leukotriene D4/thromboxane A2 雙重抑制劑，具有平喘作用。靶點
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LTD 4
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TXA 2 Receptor
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體內(nèi)研究
RS-601 (1-10 mg/kg) clearly inhibits the bronchoconstriction induced by intravenous administration of U-46619 and LTD4 in a dose-dependent fashion in guinea pigs. RS-1452 (10 mg/kg) significantly inhibits U-46619-induced bronchoconstriction, respectively. RS-601 significantly inhibits the late-phase response and LPS-induced AHR at a dose of 10 mg/kg, but does not affect biphasic bronchial responses. RS-601 (3 and 10 mg/kg) also clearly inhibits the AHR.