20788-07-2
中文名稱
雷瑣太爾
英文名稱
Resorantel
CAS
20788-07-2
分子式
C13H10BrNO3
分子量
308.13
MOL 文件
20788-07-2.mol
更新日期
2024/11/11 14:51:01
20788-07-2 結(jié)構(gòu)式
基本信息
中文別名
雷瑣太爾雷瑣泰爾 標準品
N-(4-溴苯基)-2,6-二羥基苯甲酰胺
英文別名
RESORANTELPesorantelum
N-(4-Bromophenyl)-2,6-dihydroxybenzamide
Benzamide, N-(4-bromophenyl)-2,6-dihydroxy-
物理化學性質(zhì)
熔點229-230°; mp 183-186° (LeMaire)
沸點391.1±42.0 °C(Predicted)
密度1.699±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,2-8°C
溶解度DMSO : 250 mg/mL (811.35 mM; Need ultrasonic)
酸度系數(shù)(pKa)7.62±0.35(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Resorantel是一種安全的抗絳蟲藥，對莫尼茨絳蟲和Thysaniezia spp.十分有效，對Paramphistomum spp.有一定效力。體內(nèi)研究
Resorantel (65 mg/kg, a single oral dose) possesses efficacy against paramphistomiasis in naturally infected sheep.
| Animal Model: | Five flocks of sheep in different villages of Haryana. |
| Dosage: | 65 mg/kg. |
| Administration: | A single oral dose. |
| Result: | None of the treated sheep died of enteric paramphistomiasis. The clinical signs disappeared within 2 to 3 days of the treatment and their appetite and general condition improved. No ill effects of the drug were noticed. Of the untreated sheep, 35 % died with a range of 24-52 % in the different flocks. Many of the other untreated sheep continued to exhibit clinical signs of paramphistomiasis. |