成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>2070009-55-9

2070009-55-9

中文名稱 化合物 T12434
英文名稱 Benzamide, N-[(1S)-2-[4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl]-1-[[[2-(dimethylamino)acetyl]amino]methyl]ethyl]-3-chloro-4-(1-methylethoxy)-
CAS 2070009-55-9
分子式 C29H36ClN5O4
分子量 554.08
MOL 文件 2070009-55-9.mol
更新日期 2024/12/05 21:11:24
2070009-55-9 結(jié)構(gòu)式 2070009-55-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 T12434
英文別名
Benzamide, N-[(1S)-2-[4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl]-1-[[[2-(dimethylamino)acetyl]amino]methyl]ethyl]-3-chloro-4-(1-methylethoxy)-

物理化學(xué)性質(zhì)

密度1.22±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 32 mg/mL (57.75 mM)
酸度系數(shù)(pKa)13.32±0.46(Predicted)
形態(tài)Solid
顏色White to off-white

常見(jiàn)問(wèn)題列表

生物活性
PF-2771 是一種選擇性的著絲粒蛋白 E (CENP-E) 抑制劑,IC50 值為 16.1 nM,具有抗腫瘤活性。
靶點(diǎn)

CENP-E

16.1 nM (IC 50 )

體外研究

PF-2771 is a potent and selective CENP-E inhibitor, inhibiting CENP-E motor activity with an IC 50 of 16.1 nM. PF-2771 shows no inhibitory effect on the ATPase activities of highly related kinesins (0% inhibition of Eg5/KSP, chromokinesin, and MCAK at both 1 or 10 μM PF-2771). PF-2771 exhibits inactive activity against 74 protein kinases (all < 23% inhibition with 1 μM PF-2771, < 40% with 10 μM PF-2771). PF-2771 is cytotoxic to the basal-like breast cancer tumor cell survival, with EC 50 s of < 0.1 μM, and with no cytotoxicity on the normal and premalignant cell lines (EC 50 > 5 μM). PF-2771 (100 nM) reusults in a chromosomal congression defect in MDA-MB-468 cells.

體內(nèi)研究

PF-2771 (100 mg/kg, every day i.p.) potently inhibits CENP-E motor function, and causes tumor regression in SCID mice bearing AA1077 mammary tumors.

"2070009-55-9" 相關(guān)產(chǎn)品信息