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206658-92-6

中文名稱 9-氨基-1,2,3,4-四氫吖啶 鹽酸鹽 水合物
英文名稱 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%
CAS 206658-92-6
分子式 C13H17ClN2O
分子量 252.74
MOL 文件 206658-92-6.mol
更新日期 2024/10/29 16:53:36
206658-92-6 結(jié)構(gòu)式 206658-92-6 結(jié)構(gòu)式

基本信息

中文別名
他克林鹽酸鹽
鹽酸他克林水合物
他克林鹽酸鹽水合物
THA 鹽酸鹽 水合物
單滿吖啶氨 鹽酸鹽 水合物
英文別名
Tacrine HCl hydrate
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)284-286°C (lit.)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度在水中可溶
形態(tài)粉末
顏色淡黃色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
警示詞危險(xiǎn)
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25-36/37/38-40
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII
WGK Germany3
海關(guān)編碼2933998090
9-氨基-1,2,3,4-四氫吖啶 鹽酸鹽 水合物價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08S36399-氨基-1,2,3,4-四氫吖啶 鹽酸鹽 水合物
Tacrine hydrochloride hydrate
206658-92-625mg1040.61元
2024/11/08S3639Tacrine hydrochloride hydrate206658-92-61g7944.3元

常見問題列表

生物活性
Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) 是膽堿酯酶(cholinesterase)抑制劑,可對(duì)抗骨骼肌松弛藥的作用,可作為呼吸興奮劑并用于治療阿茲海默病和其他中樞神經(jīng)系統(tǒng)障礙。它也是組胺N-甲基轉(zhuǎn)移酶(histamine N-methyltransferase)抑制劑。
靶點(diǎn)
TargetValue
HNMT
()
cholinesterase
()
體外研究

Tacrine hydrochloride hydrate (12.5 to 37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. The IC 50 is 31 nM for snake venom AChE and 25.6 nM for human BChE.

體內(nèi)研究

Pretreatment with Tacrine hydrochloride hydrate also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride hydrate. Delivery of Tacrine hydrochloride hydrate by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride hydrate treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to Tacrine hydrochloride hydrate- but not saline- treated rats evaluated by conditioned-place preference.

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