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2059892-29-2

中文名稱 MS-453
英文名稱 MS-453
CAS 2059892-29-2
分子式 C20H27N5O3
分子量 385.46
MOL 文件 2059892-29-2.mol
2059892-29-2 結構式 2059892-29-2 結構式

基本信息

中文別名
化合物 T28116
英文別名
MS-453

應用領域

用途一
MS453 is a potent and selective SETD8 inhibitor. MS453 specifically modifies a cysteine residue near the inhibitor binding site, has an IC50 value of 804 nM, reacts with SETD8 with nearquantitative yield, and is selective for SETD8 against 28 other methyltransferases. SETD8 (also known as SET8, R-SET7, or KMT5A) is the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). SETD8 inhibitors could be valuable anticancer agents.
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