205640-90-0
中文名稱
促食素A
英文名稱
Orexin A (bovine, human, mouse, rat)
CAS
205640-90-0
分子式
C152H247N47O44S4
分子量
3565.14
MOL 文件
205640-90-0.mol
更新日期
2024/10/30 11:22:55
205640-90-0 結(jié)構(gòu)式
基本信息
中文別名
下視丘分泌素PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2(DISULFIDE BRIDGE: CYS6-CYS12, CYS7-CYS14)
英文別名
OREXIN AHYPOCRETIN
Hypocretin 1
OREXIN A (HUMAN, RAT, MOUSE)
M.W. 3561.12 C152H243N47O44S4
OREXINS OREXIN A HUMAN, RAT, MOUSE
OREXIN A, BOVINE, HUMAN, MOUSE, RAT
OREXIN A (HUMAN, BOVINE, MOUSE, RAT)
OREXIN A (HUMAN, BOVINE, RAT, MOUSE)
OREXIN-A (HUMAN) (RAT, MOUSE, BOVINE)
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
密度1.53±0.1 g/cm3(Predicted)
儲(chǔ)存條件-15°C
溶解度Soluble to 1 mg/ml in sterile
形態(tài)結(jié)晶固體
顏色White to off-white
水溶解性Soluble in water at 1mg/ml
序列Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-IIE-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
促食素A價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 1mg | 4400元 |
| 2023/03/20 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 5mg | 18000元 |
常見問題列表
生物活性
Orexin A human, rat, mouse 是一種 33 氨基酸興奮性神經(jīng)肽，參與多種中樞和外周過程。Orexin A human, rat, mouse 是一種特異性、高親和力的 G 蛋白偶聯(lián)受體 OX1R 激動(dòng)劑，在調(diào)節(jié)攝食行為中起重要作用。Orexin A human, rat, mouse 是一種有效的抗傷害和抗痛覺過敏的藥物。體外研究
Orexin A human, rat, mouse has high affinity for OX1R, with 38 nM IC 50 and 34 nM EC 50 values in the the [Ca 2﹢ ]i transient assay.
體內(nèi)研究
Orexin A human, rat, mouse (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively.
Orexin A human, rat, mouse (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg.
| Animal Model: | Female mice (mouse carrageenan-induced thermal hyperalgesia test) |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | i.v.; 5 min pre-test |
| Result: | Significantly increased the latency to response at 10 and 30 mg/kg. |