2046250-48-8
中文名稱
K67
英文名稱
K67
CAS
2046250-48-8
分子式
C29H30N2O7S2
分子量
582.69
MOL 文件
2046250-48-8.mol
更新日期
2024/06/25 17:15:58
2046250-48-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)752.2±70.0 °C(Predicted)
密度1.357±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 10mg/mL, clear
酸度系數(shù)(pKa)8.33±0.30(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
應(yīng)用領(lǐng)域
用途一
K67 is a specific inhibitor against the interaction between KEAP1 DC domain and S349-phosphorylated KIR of p62/SQSTM1, K67 effectively inhibits the proliferation of HCC cultures with high cellular p62 S351-phosphorylation by restoring KEAP1-driven NRF2 ubiquitination and degradation.