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204077-66-7

中文名稱 KF-31327
英文名稱 Thioquinapiperifil Dihydrochloride
CAS 204077-66-7
分子式 C24H30Cl2N6OS
分子量 521.506
MOL 文件 204077-66-7.mol
更新日期 2024/08/14 18:49:52
204077-66-7 結(jié)構(gòu)式 204077-66-7 結(jié)構(gòu)式

基本信息

中文別名
3-乙基-8-[2-(4-羥甲基哌啶子基)芐氨基]-2,3-二氫-1H-咪唑并[4,5-G]喹唑啉-2-硫酮二鹽酸鹽
英文別名
AXWNTYWYZQARCG-UHFFFAOYSA-N
Thioquinapiperifil Dihydrochloride

物理化學(xué)性質(zhì)

儲存條件4°C, protect from light
溶解度DMSO : 125 mg/mL (239.69 mM)
形態(tài)Solid
顏色Light yellow to yellow

常見問題列表

生物活性
Thioquinapiperifil dihydrochloride (KF31327) 是有效的、選擇性的、非競爭性的磷酸二酯酶 (PDE-5) (IC50 為 0.074 nM) 的抑制劑，可用于性成熟的研究。
靶點(diǎn)

PDE5

0.074 nM (IC 50 )

PDE1

380 nM (IC 50 )

PDE2

670 nM (IC 50 )

PDE3

38 nM (IC 50 )

PDE4

800 nM (IC 50 )

體外研究

Thioquinapiperifil can be found in dietary supplements.
Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil dihydrochloride (KF31327) are required to inhibit platelet aggregation.
Thioquinapiperifil dihydrochloride (KF31327) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil dihydrochloride (KF31327)-treated cells is 0.95±0.17 pmol/10 8 cells.

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