202402-01-5
中文名稱
GET 73;GET-73;GET73
英文名稱
GET-73
CAS
202402-01-5
分子式
C13H16F3NO2
分子量
275.27
MOL 文件
202402-01-5.mol
更新日期
2024/10/25 11:12:38
202402-01-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)394.7±42.0 °C(Predicted)
密度1.175±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度DMSO : 100 mg/mL (363.28 mM; Need ultrasonic)
酸度系數(shù)(pKa)15.11±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
常見問(wèn)題列表
生物活性
GET73 是一種天然神經(jīng)遞質(zhì) γ-羥基丁酸 (GHB) 的類似物。GET73 具有抗酒精和抗焦慮的特性。GET73 對(duì)谷氨酸在海馬的傳遞有顯著的影響。體外研究
GET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production.
Cell Viability Assay
| Cell Line: | Rat hippocampal neurons |
| Concentration: | 0.1 μM, 1 μM, 10 μM |
| Incubation Time: | 1 hour |
| Result: | Prevented the ethanol (75 mM, 4 days) -induced MTT reduction. |
體內(nèi)研究
GET73 (5–50?mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.
| Animal Model: | Male SD rats (200-300?g and 300–350?g) |
| Dosage: | 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg |
| Administration: | Oral gavage |
| Result: | Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test. |