2023788-32-9
中文名稱
INTEGRIN MODULATOR 1
英文名稱
2-Azetidineacetic acid, 1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-
CAS
2023788-32-9
分子式
C13H14N2O4
分子量
262.26
MOL 文件
2023788-32-9.mol
更新日期
2023/03/20 15:41:27
2023788-32-9 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.413±0.06 g/cm3(Predicted)
儲(chǔ)存條件4°C, away from moisture and light
溶解度DMSO: 100 mg/mL (381.30 mM)
酸度系數(shù)(pKa)4.20±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Integrin modulator 1 是一種有效和選擇性的 α4β1 整聯(lián)蛋白激動(dòng)劑，IC50 值為 9.8 nM。Integrin modulator 1 增加了 α4β1 整聯(lián)蛋白介導(dǎo)的細(xì)胞粘附，EC50 值為 12.9 nM。靶點(diǎn)
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α4β1 9.8 nM (IC 50 ) |
體外研究
Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion.
Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells.
Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner.