200940-23-4
200940-23-4 結(jié)構(gòu)式
基本信息
SB 243213 dihydrochloride
2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2023/03/20 | HY-103112 | SB 243213 HYDROCHLORIDE SB 243213 hydrochloride | 200940-23-4 | 5mg | 900元 |
| 2023/03/20 | HY-103112 | SB 243213 HYDROCHLORIDE SB 243213 hydrochloride | 200940-23-4 | 10mg | 1500元 |
| 2023/03/20 | HY-103112 | SB 243213 HYDROCHLORIDE SB 243213 hydrochloride | 200940-23-4 | 25mg | 3500元 |
常見(jiàn)問(wèn)題列表
|
Human 5-HT 2C Receptor 9.37 (pKi) |
human 5-HT 1A Receptor <5.3 (pKi) |
human 5-HT 1B Receptor 5.5 (pKi) |
human 5-HT 1D Receptor 6.32 (pKi) |
human 5-HT 1E Receptor <5.4 (pKi) |
human 5-HT 1F Receptor 5.35 (pKi) |
Human 5-HT 2A Receptor 7.01 (pKi) |
human 5-HT 2B Receptor 7.2 (pKi) |
Human 5-HT 6 Receptor 6.5 (pKi) |
Human 5-HT 7 Receptor 5.64 (pKi) |
SB 243213 hydrochloride shows little affinity (pK
i
<6) for cloned human 5-HT
1A
, 5-HT
1B
, 5-HT
1E
, 5- HT
1F
and 5-HT
7
receptors. It shows weak affinity (pK
i
<6.5) for the cloned human 5-HT
1D
and D3 receptors and moderate affinity (pK
i
=6.7) for the cloned human D2 receptor.
SB 243213 hydrochloride shows 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels.
SB 243213 hydrochloride (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
SB 243213 hydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction.
| Animal Model: | Male Sprague-Dawley experimentally naive rats (220-300 g) |
| Dosage: | 0.1, 0.3, 1, 3, 10 mg/kg |
| Administration: | PO; 1 hour pre-test |
| Result: | Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. |