200803-37-8
中文名稱
200803-37-8
英文名稱
OSIP-486823
CAS
200803-37-8
分子式
C29H28FNO4
分子量
473.54
MOL 文件
200803-37-8.mol
更新日期
2023/03/20 15:41:17
200803-37-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13807 英文別名
CP248OSIP-486823
1H-Indene-3-acetamide, 5-fluoro-2-methyl-N-(phenylmethyl)-1-[(3,4,5-trimethoxyphenyl)methylene]-, (1Z)-
物理化學(xué)性質(zhì)
沸點(diǎn)667.3±55.0 °C(Predicted)
密度1.206±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)15.72±0.46(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
OSIP-486823 是一種新型的微管干擾劑，對(duì)蛋白激酶 G (PKG) 和微管均具有生物學(xué)作用。靶點(diǎn)
Microtubule
體外研究
OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC 50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells.