200619-13-2
中文名稱
DRF-1042
英文名稱
DRF-1042
CAS
200619-13-2
分子式
C22H20N2O6
分子量
408.4
MOL 文件
200619-13-2.mol
更新日期
2024/10/09 11:06:39
200619-13-2 結(jié)構(gòu)式
基本信息
中文別名
(4S)-4-乙基-4-羥基-12-(2-羥基乙氧基)-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-B]喹啉-3,14(4H,12H)-二酮 英文別名
DRF-1042(4S)-4-Ethyl-4-hydroxy-12-(2-hydroxyethoxy)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-12-(2-hydroxyethoxy)-, (4S)-
物理化學(xué)性質(zhì)
沸點(diǎn)844.6±65.0 °C(Predicted)
密度1.53±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 50 mg/mL (122.43 mM)
酸度系數(shù)(pKa)11.13±0.40(Predicted)
形態(tài)Solid
顏色White to light yellow
DRF-1042價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-125331 | DRF-1042 DRF-1042 | 200619-13-2 | 5mg | 800元 |
| 2024/08/19 | HY-125331 | DRF-1042 DRF-1042 | 200619-13-2 | 10mM * 1mLin DMSO | 880元 |
| 2024/08/19 | HY-125331 | DRF-1042 DRF-1042 | 200619-13-2 | 10mg | 1300元 |
常見(jiàn)問(wèn)題列表
生物活性
DRF-1042 是一種具有口服活性的喜樹(shù)堿類似物，具有抑制 DNA 拓?fù)洚悩?gòu)酶 I (DNA topoisomerase I) 的作用。DRF-1042 對(duì)一組人癌細(xì)胞株，包括多藥耐藥 (MDR)表型，顯示出良好的抗癌活性。靶點(diǎn)
DNA topoisomerase I
體外研究
DRF-1042 demonstrates superior lactone stability and good in vitro anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype.
體內(nèi)研究
In clonogenic assay against murine, canine and human bone marrow cells, DRF-1042 treatment shows less mylosupression that supports the possibility of protracted dose schedule in both experimental and clinical studies.