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195883-06-8

中文名稱 昂曲托來(lái)
英文名稱 Omtriptolide
CAS 195883-06-8
分子式 C24H28O9
分子量 460.47
MOL 文件 195883-06-8.mol
更新日期 2023/03/20 15:41:25
195883-06-8 結(jié)構(gòu)式 195883-06-8 結(jié)構(gòu)式

基本信息

中文別名
昂曲托來(lái)
英文別名
OMTRIPTOLIDE
Unii-D36elm729p
Butanedioic acid, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, 1-[(3bS,4aS,5aR,6R,6aS,7aS,7bS,8aS,8bS)-1,3,3b,4,4a,6,6a,7a,7b,8b,9,10-dodecahydro-8b-methyl-6a-(1-methylethyl)-1-oxotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-6-yl] ester

物理化學(xué)性質(zhì)

熔點(diǎn)109-111 ºC
沸點(diǎn)691.4±55.0 °C(Predicted)
密度1.49
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.36±0.17(Predicted)
形態(tài)Solid
顏色White to off-white
昂曲托來(lái)價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/08HY-16363昂曲托來(lái)
Omtriptolide
195883-06-81mg1500元
2025/02/08HY-16363昂曲托來(lái)
Omtriptolide
195883-06-85mg4500元
2025/02/08HY-16363昂曲托來(lái)
Omtriptolide
195883-06-810mM * 1mLin DMSO4559元

常見(jiàn)問(wèn)題列表

生物活性
Omtriptolide (PG490-88) 是從中草藥純化的雷公藤內(nèi)酯的水溶性衍生物前藥。
靶點(diǎn)

ERK

體外研究

Triptolide, a traditional Chinese medicine, has anti-inflammatory, antiproliferative, and proapoptotic properties.

體內(nèi)研究

In a mouse model of cisplatin-induced AKI, omtriptolide results in a significant decrease in blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) score, and a nonsignificant increase in tubular apoptosis score in AKI. The protection of omtriptolide against AKI is associated with a decrease in p-ERK and is independent of MKP-1 and proinflammatory cytokines. In a mouse heterotopic tracheal allograft model of obliterative airway disease, omtriptolide attenuates airway obliteration and inhibits accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease following lung transplantation. Omtriptolide inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. Omtriptolide also markedly reduces the number of myofibroblasts in the bleomycin treatment group. Omtriptolide inhibits in vivo both CD4+Vbeta3+ and CD8+Vbeta3+ T cell (alloreactive T cells in this model) expansion in the spleen by 64.09 and 34.02%, respectively, at the time when Vbeta3+ cell expansion is in the logarithmic phase (day 3 after transplantation).

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