1903800-11-2
1903800-11-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15662 英文別名
KIN1408KIN-1408 (KIN-1408
KIN1408 >=98% (HPLC)
8-Quinolinol, 7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-
7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol)
KIN-1408
KIN 1408
7-((4-(DIFLUOROMETHOXY)PHENYL)((5-METHOXYBENZO[D]THIAZOL-2-YL)AMINO)METHYL)QUINOLIN-8-OL
物理化學(xué)性質(zhì)
沸點(diǎn)675.6±65.0 °C(Predicted)
密度1.430±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO:34.5(Max Conc. mg/mL);71.95(Max Conc. mM)
酸度系數(shù)(pKa)4.22±0.50(Predicted)
形態(tài)固體
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
KIN1408 是 RIG-1-like 受體 (RLR) 途徑的激動(dòng)劑，并具有廣譜抗病毒活性。KIN1408 對(duì) HCV，influenza A，dengue virus 2，Ebola，Nipah 和 Lassa viruses 具有抗性。體外研究
KIN1408 has the potency to drive IRF3 activation to induce innate immune gene (MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells) expression and that concomitantly suppress dengue virus2 RNA to levels. KIN1408 also exhibits activity against HCV, influenza A, Ebola, Nipah, and Lassa viruses.