18942-26-2
中文名稱
訶子林鞣酸
英文名稱
CHEBULINIC ACID
CAS
18942-26-2
分子式
C41H32O27
分子量
956.68
MOL 文件
18942-26-2.mol
更新日期
2025/04/02 09:09:08
18942-26-2 結(jié)構(gòu)式
基本信息
中文別名
柯黎勒酸訶子林鞣酸
訶子林鞣酸對照品
訶子林鞣酸(標(biāo)準(zhǔn)品)
英文別名
EutanninNSC69862
CHEBULINIC ACID
CHEBULINIC ACID(SH)
CHEBULINIC ACID USP/EP/BP
Chebulinic acid >=85% (LC/MS-ELSD)
b-D-Glucopyranose,1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 22:41-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioicacid
β-D-Glucopyranose, 1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid
所屬類別
生物化工：植物提取物物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶粉末。
沸點1460.0±65.0 °C(Predicted)
密度2.04
儲存條件-20°C
溶解度Soluble in acetone, methanol and hot water; insoluble in chloroform and n-hexane
酸度系數(shù)(pKa)4.14±0.10(Predicted)
形態(tài)粉末
顏色米色
InChIKeyYGVHOSGNOYKRIH-KOPSEHRPNA-N
訶子林鞣酸價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-N2033 | 訶子林鞣酸 Chebulinic acid | 18942-26-2 | 1 mg | 800元 |
| 2025/02/08 | HY-N2033 | 訶子林鞣酸 Chebulinic acid | 18942-26-2 | 5mg | 2000元 |
| 2025/02/08 | HY-N2033 | 訶子林鞣酸 Chebulinic acid | 18942-26-2 | 10mg | 3200元 |
常見問題列表
生物活性
Chebulinic acid 是一個天然的M. tuberculosis DNA gyrase抑制劑，也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。靶點
target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]
體外研究
In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]