1883650-95-0
中文名稱
CPD1589
英文名稱
CDDO-2-P-Im
CAS
1883650-95-0
分子式
C39H46N4O3
分子量
618.81
MOL 文件
1883650-95-0.mol
更新日期
2024/10/24 11:25:04
1883650-95-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13603化合物CDDO-3P-IM
英文別名
CPD1589CPDB1589
CDDO-2-P-Im
CDDO-3P-Imidazolide
Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(3-pyridinyl)-1H-imidazol-1-yl]-
物理化學(xué)性質(zhì)
沸點(diǎn)771.1±70.0 °C(Predicted)
密度1.25±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (404.00 mM)
酸度系數(shù)(pKa)3.34±0.12(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
CDDO-3P-Im 是 CDDO 咪唑胺類似物，具有化學(xué)預(yù)防作用。CDDO-3P-Im 可降低小鼠肺癌模型肺腫瘤的大小和嚴(yán)重程度。CDDO-3P-Im 是一種具有口服活性的壞死 (necroptosis) 抑制劑，可用于缺血/再灌注 (I/R) 的研究。體外研究
CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM.
CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 4.3 nM.
Apoptosis Analysis
| Cell Line: | U937 cells |
| Concentration: | 30 nM, 100 nM |
| Incubation Time: | 4 days |
| Result: | Induced differentiation of U937 cells at 30 nM. |
體內(nèi)研究
CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
| Animal Model: | Seven week-old female A/J mice |
| Dosage: | 50 mg/kg, 200 mg/kg |
| Administration: | Diet; for 16 weeks |
| Result: | Decreased the number, the size and the severity of tumors. |