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182959-28-0

中文名稱 182959-28-0
英文名稱 YM-53601 free base
CAS 182959-28-0
分子式 C21H21FN2O
分子量 336.4
MOL 文件 182959-28-0.mol
182959-28-0 結(jié)構(gòu)式 182959-28-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T13371
英文別名
YM-53601 free base
9H-Carbazole, 2-[2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, (E)- (9CI)

物理化學(xué)性質(zhì)

沸點(diǎn)541.2±40.0 °C(Predicted)
密度1.30±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)16.62±0.30(Predicted)

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335

常見問題列表

生物活性
YM-53601 free base是角鯊烯合成酶抑制劑,其抑制嚙齒類動物的脂肪生物合成和脂質(zhì)分泌。
靶點(diǎn)

Target: Squalene synthetase

體內(nèi)研究

YM-53601 inhibits cholesterol biosynthesis from acetate in a dose-dependent manner in the plasma of rats. At the same time, YM-53601 inhibits both FFA and triglyceride biosynthesis in rats treated with cholestyramine over the same dose range at which it inhibits cholesterol biosynthesis. YM-53601 by single oral administration decreases the enhanced plasma triglyceride levels in hamsters induced by an injection of protamine sulfate, which inhibits lipoprotein lipase (LPL) and consequently increases plasma very low-density lipoprotein (VLDL) triglyceride levels. YM-53601 also decreases the enhanced plasma triglyceride and cholesterol levels in hamsters treated with Triton WR1339, which also inhibits the degradation of VLDL. Plasma cholesterol was significantly decreased as soon as 1 h after single administration of YM-53601 in hamsters fed a normal diet.

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