1821107-98-5
中文名稱
化合物 T27195
英文名稱
Methanone, (3-bromo-4-fluorophenyl)[(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-1-piperidinyl]-
CAS
1821107-98-5
分子式
C18H15BrF3N5O
分子量
454.24
MOL 文件
1821107-98-5.mol
1821107-98-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27195 英文別名
DNS8254DNS-8254
DNS 8254
Methanone, (3-bromo-4-fluorophenyl)[(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-1-piperidinyl]-
應用領(lǐng)域
用途一
DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) Inhibitor for the Treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/mimg). In vivo, DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object recognition. DNS-8254 may be a useful tool to explore the pharmacology of selective PDE2a inhibition.