1817791-73-3
1817791-73-3 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.27±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13?+-.0.70(Predicted)
形態(tài)Solid
顏色White to yellow
應(yīng)用領(lǐng)域
用途一
NTRC-0066-0 is a a highly potent and selective small molecule inhibitor of TTK. In cell lines and in mice, NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenografts as a single agent after oral application. The combination of NTRC 0066-0 with a therapeutic dose of docetaxel resulted in doubling of mouse survival and extended tumor remission, without toxicity.