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181427-66-7

中文名稱 β-Amyloid (10-35), amide
英文名稱 β-Amyloid (10-35), amide
CAS 181427-66-7
分子式 C133H205N35O36S
分子量 2902.37
MOL 文件 181427-66-7.mol
181427-66-7 結(jié)構(gòu)式 181427-66-7 結(jié)構(gòu)式

基本信息

中文別名
Β-AMYLOID (10-35), AMIDE
英文別名
β-Amyloid (10-35)
β-Amyloid (10-35), amide

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
β-Amyloid (10-35), amide價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2023/03/20HY-P1567β-Amyloid (10-35), amide
β-Amyloid (10-35), amide
181427-66-71mg1000元
2023/03/20HY-P1567β-Amyloid (10-35), amide
β-Amyloid (10-35), amide
181427-66-75mg3300元
2023/03/20HY-P1567β-Amyloid (10-35), amide
β-Amyloid (10-35), amide
181427-66-710mg5200元

常見問題列表

生物活性
β-Amyloid (10-35), amide 是一種含有 26 個(gè)氨基酸的多肽,由 β-Amyloid 肽的 10-35 殘基組成。β-Amyloid (10-35) 是阿爾茲海默癥淀粉樣斑塊 (Alzheimer’s disease) 的主要組成成分。
體外研究

β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ (1-42) , is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils.

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