1801343-74-7
中文名稱
CA-4948
英文名稱
CA-4948
CAS
1801343-74-7
分子式
C21H19N7O3
分子量
417.42
MOL 文件
1801343-74-7.mol
更新日期
2024/11/14 17:46:48
1801343-74-7 結(jié)構(gòu)式
基本信息
中文別名
6'-AMINO-N-[2-(4-MORPHOLINYL)OXAZOLO[4,5-B]PYRIDIN-6-YL][2,3'-BIPYRIDINE]-6-CARBOXAMIDE 英文別名
CA-4948IRAK4-IN-7
CA4948-Analog
CA 4948
CA4948
CA 4948, CA-4948, CA4948
6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide
[2,3'-Bipyridine]-6-carboxamide, 6'-amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl]-
所屬類別
醫(yī)藥中間體：雜環(huán)化合物物理化學(xué)性質(zhì)
熔點(diǎn)>294°C (dec.)
密度1.444±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C Freezer, Under inert atmosphere
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)10.41±0.43(Predicted)
形態(tài)固體
顏色淡黃色至棕色
InChIInChI=1S/C21H19N7O3/c22-18-5-4-13(11-23-18)15-2-1-3-16(26-15)20(29)25-14-10-17-19(24-12-14)27-21(31-17)28-6-8-30-9-7-28/h1-5,10-12H,6-9H2,(H2,22,23)(H,25,29)
InChIKeyRWIMETUXCNDSLE-UHFFFAOYSA-N
SMILESC1(C2=CC=C(N)N=C2)=NC(C(NC2=CN=C3N=C(N4CCOCC4)OC3=C2)=O)=CC=C1
應(yīng)用領(lǐng)域
用途1
一種可逆性激酶抑制劑，在TLR和IL-1R信號(hào)級(jí)聯(lián)反應(yīng)中，調(diào)節(jié)IRAK4的功能。在體內(nèi)外實(shí)驗(yàn)中，具有良好的藥代動(dòng)力學(xué)特征和抗腫瘤活性。CA-4948 is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. CA-4948 exhibited the greatest efficacy in four of the five ABC-DLBCL PDX models tested as compared to GBC-DLBCL and ABC/GCB DLBCL PDX models. Furthermore, CA-4948 was efficacious in ABC-DLBCL PDX tumors containing activating mutations in both TLR/IL-1R and BCR signaling pathways (MYD88 and CD79B double mutants).