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179986-89-1

中文名稱 PANCREATIC POLYPEPTIDE (BOVINE)
英文名稱 PANCREATIC POLYPEPTIDE (BOVINE)
CAS 179986-89-1
更新日期 2024/11/01 16:18:36
179986-89-1 結(jié)構(gòu)式 179986-89-1 結(jié)構(gòu)式

基本信息

中文別名
胰腺多肽,牛
英文別名
PANCREATIC POLYPEPTIDE (BOVINE)
Pancreatic polypeptide (pig),6-L-glutamic acid-
H-Ala-Pro-Leu-Glu-Pro-Glu-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Glu-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
Pancreatic Polypeptide, bovine 是由 36 個(gè)氨基酸組成的直鏈多肽,由胰腺中產(chǎn)生,能夠抑制由分泌素和膽囊素誘導(dǎo)的胰腺分泌。Pancreatic Polypeptide, bovine 是神經(jīng)肽 (NPY) 受體激動(dòng)劑,對(duì) NPYR4 有很高的親和性。
靶點(diǎn)

NPYR4

體外研究

Pancreatic Polypeptide, bovine is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2+ ) i levels in BRIN BD11 cells at 1 μM. Pancreatic Polypeptide, bovine inhibits secretin- and cholecystokinin-stimulated pancreatic secretion. 125 I-Pancreatic Polypeptide, bovine shows no specific binding to pancreatic acini.

體內(nèi)研究

Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice. Pancreatic Polypeptide, bovine (BPP; 40 μg/kg) inhibits CCK-33-induced pancreatic protein output during the entire bovine Pancreatic Polypeptide infusion period, but shows no effect on biliary protein output during CCK-33 or CCK-8 infusion.

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