179343-17-0
179343-17-0 結(jié)構(gòu)式
基本信息
N-[2-氨基-6-(2,6-二氯苯基)吡啶基[2,3-d]嘧啶-7-基]-N'-叔丁基脲
1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
Urea, N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
|
FGFR1 0.15 μM (IC 50 ) |
PDGFR-β 1.76 μM (IC 50 ) |
EGFR 5.47 μM (IC 50 ) |
c-Src 0.18 μM (IC 50 ) |
FGFR1 0.14 μM (Ki) |
PDGFR-β 2.38 μM (Ki) |
EGFR 3.16 μM (Ki) |
c-Src 0.1 μM (Ki) |
PD-089828 (0.5-20 μM; 2 hours) inhibits PDGFR autophosphorylation with an IC
50
of 0.82 μM.
PD-089828 (1-50 μM; 2 hours) inhibits EGFR autophosphorylation with an IC
50
value of 10.9 μM.
In A121(p) cells, PD 089828 potently inhibits the phosphorylation of FGFR-1 with an IC
50
value of 0.63 μM.
PD-089828 (10 μM; 8 days) produces a concentration-related inhibition of serum-stimulated cell growth with an IC
50
value of 1.8 μM.
PD-089828 inhibits increases in DNA synthesis stimulated by all three growth factors, with IC
50
values of 0.8 for PDGF-, 1.7 for EGF- and 0.48 μM for bFGF-induced mitogenesis.
Cell Proliferation Assay
| Cell Line: | Vascular smooth muscle cells (serum-stimulated growth) |
| Concentration: | 10 μM |
| Incubation Time: | 8 consecutive days |
| Result: | Produced a concentration-related inhibition of serum-stimulated cell growth with an IC50 value of 1.8 μM. |
Western Blot Analysis
| Cell Line: | Vascular smooth muscle cells (stimulated with PDGF-BB 30 ng/ml) |
| Concentration: | 0.5-20 μM |
| Incubation Time: | 2 hours |
| Result: | Inhibited PDGFR autophosphorylation with an IC 50 of 0.82 μM. |